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Tuesday, August 16, 2016

Draper Develops Artificial Lung Technology to Treat Patients Suffering from Short-Term Respiratory Failure

Device will provide bridge to lung transplant or patient recovery without ventilator or ECMO side effects

CAMBRIDGE, MA – Draper has developed an artificial lung technology to treat temporary respiratory failure until the patient either recovers or gets a lung transplant.

Until now, doctors have largely used highly invasive medical ventilation devices or extracorporeal membrane oxygenator (ECMO) therapy. Ventilation devices provide oxygen support and remove carbon dioxide from critically ill patients, although severe complications can arise with these devices, including barotrauma (high pressures), hypertension of the lung parenchyma, increased risk for ventilator-induced pneumonia, oxygen toxicity, and even death. An alternative to ventilators, ECMO therapy uses equipment that bypasses the lungs to deliver oxygen directly to the blood. But ECMO doesn’t mimic the patterns in which blood flows through the blood vessel networks in the body. This results in patients often suffering from blood clotting, which requires doctors to administer anticlotting agents that carry their own side effects.

Draper has developed a better solution. The technology is outlined in a paper that was recently published in Lab on a Chip published by the esteemed Royal Society of Chemistry.

Draper engineers, who have developed technologies to treat failure of the liver, kidneys and other organs, created their biomimetic microfluidic oxygen transfer device to exchange levels of oxygen and carbon dioxide to mimic the natural human lung. The prototype builds on current ECMO technology by incorporating microfluidic techniques to more closely mimic how blood flows in the human lung. Draper fabricated and tested the multilayer, microfluidic blood oxygenation device to demonstrate that it had a lower blood prime volume and improved blood circulation, and collaborated with investigators at Brigham and Women’s Hospital who designed experimental procedures to develop the lining of the device with human endothelial cells, thus mimicking the anti-thrombotic surface present in human capillaries.

“Our technology is designed to overcome the problems with current ventilators and with current ECMO,” said Jeff Borenstein, Laboratory Technical Staff at Draper. “The mechanical ventilators force oxygen through damaged lungs, so the idea to move to ECMO is to let the lungs rest and to exchange oxygen and carbon dioxide directly with the blood. We, together with our Brigham and Women’s Hospital collaborator Dr. Guillermo Garcia-Cardena, associate professor of Pathology at Harvard Medical School, are trying to make a superior technology that improves the safety of ECMO. The problem with ECMO technology today is the blood tends to clot very rapidly in ECMO machines, and the way doctors get around that is to administer anticlotting agents, so patients end up in a dangerous balance between clotting and bleeding. Our technology aims to overcome this problem by making the device channels that the blood flows through more biologically relevant and mimicking endothelial-lined capillary networks in the body.”

Initially, the work began as an IR&D (independent research and development) project, but there was so much promise in the biomimetic microfluidic oxygen transfer device, eventually, engineers received funding from the National Institutes of Health (NIH). Draper quickly proved its viability. Today, the product has advanced toward a commercial path. Draper currently is working toward establishing a commercial partner for the technology. There are other technologies being developed toward clinical application, but Draper’s technology is the only one with the important distinction of a biomimetic/microfluidic design.

The device is expected to undergo animal testing over the next two years and is roughly three to four years away from clinical use. Draper’s ultimate goal is to create a device that can be used long term, like an oxygen tank, as a more permanent solution for lung failure.

Draper multilayer microfluidic oxygenator device with biomimetic blood flow patterns, designed to provide a safer and more efficacious treatment for acute respiratory failure than either mechanical ventilation or current extracorporeal membrane oxygenator therapy.
Capabilities Used

Draper has designed and developed microelectronic components and systems going back to the mid-1980s. Our integrated, ultra-high density (iUHD) modules of heterogeneous components feature system functionality in the smallest form factor possible through integration of commercial-off-the-shelf (COTS) technology with Draper-developed custom packaging and interconnect technology. Draper continues to pioneer custom Microelectromechanical Systems (MEMS), Application-Specific Integrated Circuits (ASICs) and custom radio frequency components for both commercial (microfluidic platforms organ assist, drug development, etc.) and government (miniaturized data collection, new sensors, Micro-sats, etc.) applications.  Draper features a complete in-house iUHD and MEMS fabrication capability and has existing relationships with many other MEMS and microelectronics fabrication facilities. 

Biomedical Solutions

Draper’s Biomedical Solutions capability centers on the application of microsystems, miniaturized electronics, computational modeling, algorithm development and image and data analytics applied to a range of challenges in healthcare and related fields. Draper fills that critical engineering niche that is required to take research or critical requirements and prototype or manufacture realizable solutions.  Some specific examples are MEMS, microfluidics and nanostructuring applied to the development of wearable and implantable medical devices, organ-assist devices and drug-delivery systems. Novel neural interfaces for prosthetics and for treatment of neurological conditions are being realized through a combination of integrated miniaturized electronics and microfabrication technologies.

Materials Engineering & Microfabrication

Draper continues to develop its expertise in designing, characterizing and processing materials at the macro-, micro- and nanoscales. Understanding the physical properties and behaviors of materials at these various scales is vital to exploit them successfully in designing components or systems. This enables the development and integration of biomaterials, 3D printing and additive manufacturing, wafer fabrication, chemical and electrochemical materials and structural materials for application to system-level solutions required of government and commercial sponsors.

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